Endocrine Abstracts

Introduction/ Background: Typical (TC) and atypical carcinoids (AC) are the most common neuroendocrine tumors (NETs) of the lung. Being a rare disease, the management of these tumors varies widely among Swiss centers. The impact of guidelines introduced in 2015 is unknown.Aims: Comparison of the management of Swiss patients before and after the publication of the expert consensus of the European Neuroendocrine Tumor Society (ENETS) in 2015.<p class="...

Background and aims: Hypogonadotropic hypogonadism is characterised by inadequate secretion of gonadotropins (luteinising hormone (LH) and follicle-stimulating hormone (FSH)) leading to absent, partial or arrested puberty. In males, classical treatment with testosterone promotes virilisation but does not facilitate testicular growth or spermatogenesis. Conversely, treatment with gonadotropins or gonadotropin-releasing hormone (GnRH) stimulates Sertoli and Leydig cells directly...

Background: An activation of the hypothalamic-pituitary-adrenal (HPA) axis is a common observation in obese individuals. GLP-1 agonists, such as semaglutide, and SGLT-2 inhibitors, such as empagliflozin, are well known to be beneficial in obesity, while other incretins, like peptide tyrosine tyrosine 3-36 (PYY 3-36), might be also useful for the treatment of obesity. However, the effect of these substances on the adrenal gland is largely unknown. We directly compared the effec...

Background: Hypoparathyroidism is one of the most important complications of total thyroidectomy. Its treatment with the use of recombinant parathyroid hormone (PTH) is limited now, therefore the prophylaxis of post-surgical hypoparathyroidism is very important. A method of tension-free thyroidectomy (TFT) was proposed in 2021. TFT uses unusual medial approach to the recurrent laryngeal nerves (RLN) and parathyroid glands (PG), together with several principles decreasing tract...

Background: SARS-CoV-2 profoundly impacts population health through both acute infection and post-COVID period. Multiple studies make it clear that metabolic diseases can significantly affect the course of COVID-19.Aim: To study the course of post-COVID period in patients with type 2 diabetes mellitus (DM2).Methods: The international registry ACTIV SARS-CoV-2 (NCT04492384) was established to study COVID-19 in the Eurasian region. T...

Background: The literature shows that body mass index (BMI) and blood glucose levels can significantly influence the course of infectious diseases. In the light of ongoing SARS-CoV-2 pandemic, its rational treatment and prevention are strategic public health goals.Aim: To study the relationship between BMI and serum glucose levels during the acute period of COVID-19 in hospitalized patients.«ACTIV SARS-CoV-2» registry was established to evaluat...

Background: Nelson syndrome is a rare complication of Cushing disease (CD), which occurs either in patients with very aggressive CD or as a result of misdiagnosis. Clinical characterization of patients with Nelson syndrome could provide important insights in management of the disorder.Methods: We analyzed medical records of patients with CD between 2015 and 2021 to identify those who developed Nelson syndrome.Results: Nine patients...

Introduction: ADH-deficiency (central diabetes insipidus, ADH-D) is a rare disease, and data on worldwide and country-specific prevalence rates are scarce. ADH-D registries could provide valuable information on epidemiology, etiological distribution, treatment requirements and potentially serve as a guide for management decisions in clinical practice.Objectives: To assess the epidemiological data on ADH-D in Russian Registry for Central Diabetes Insipidu...

Background: Foxp3(+) regulatory T cells (Treg) play a leading role in developing immune tolerance through active suppression in Graves’ disease (GD). The influence of radioactive iodine therapy (RAI) on the differentiated fractions of Treg of GD patients is still poorly understood. Aim: To estimate the differentiated fractions of blood Tregs and the CD25 expression in patients with GD after RAI.Materials and Methods: In total,...

Patients with diabetes mellitus (DM) are more likely to suffer from purulent infection, probably due to compromised immune response. Achieving target levels of glycemia is a prerequisite for the perioperative management of patients with DM. However, the specific parameters of glycemic variability, optimal glucose range for the effective treatment of purulent infection of the maxillofacial region have not been established yet.Purpose: to assess the impact...